A new UBC study concludes that just two hours of exposure to diesel exhaust is enough to cause significant damage to the human body. The study, led by Dr. Chris Carlsten, looked at how pollution particles affect the way genes are expressed in the body.

The study comprised of sixteen non-smoking adult volunteers with asthma. They were put in an enclosed booth about the size of a standard bathroom and made to breathe diluted and aged exhaust fumes equal to the air quality along a Beijing highway, or a busy port in British Columbia.

Carlsten says the impact of the pollution “exceeded our expectations and quite rapidly, as it turns out. We’re showing in hours, we observe changes in the blood that may have long-term implications.”

   Dr. Chris Carlsten says short-term exposure to diesel exhaust can affect the coating on DNA


It’s believed exposure to the particles affects the chemical “coating” that can attach to parts of a person’s DNA. “That carbon-hydrogen coating, called methylation, can silence or dampen a gene, preventing it from producing a protein – sometimes to a person’s benefit, sometimes not. Methylation is one of the several mechanisms for controlling gene expression, which is the focus of a rapidly growing field of study called epigenetics,” said a statement issued by UBC.

“The study, published this month in Particle and Fibre Toxicology, found that diesel exhaust caused changes in methylation at about 2,800 different points on DNA, affecting about 400 genes. “In some places, it led to more methylation; in more cases, it decreased methylation.”

Carlsten says the next step is to figure out how to reverse the damage. The immediate challenge is to identify areas of concern within indoor environments and address solutions to mitigate the impact and exposure levels.

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